High-Protein Pizza Pasta Bake

Featured in: Cozy Dinner Plates

This satisfying casserole brings together everyone's favorite pizza flavors in a protein-packed format. Lean ground beef and sliced pepperoni provide substantial protein, while a unique Greek yogurt and cheese sauce creates creamy richness without excessive calories. The pasta bakes until perfectly tender, absorbing the savory tomato and herb flavors.

Perfect for meal prep or family dinners, this dish delivers 37 grams of protein per serving while maintaining the comforting taste of pizza. The bubbly golden top with melted mozzarella creates an irresistible finish that will have everyone coming back for seconds.

Updated on Sun, 08 Feb 2026 11:20:00 GMT
Golden, bubbling High-Protein Pizza Pasta Bake fresh from the oven, topped with crispy pepperoni slices. Save
Golden, bubbling High-Protein Pizza Pasta Bake fresh from the oven, topped with crispy pepperoni slices. | frizplo.com

My roommate challenged me to make something that felt like pizza night but could actually fuel our gym sessions, and honestly, I wasn't sure it was possible until I threw together this pasta bake one rainy Tuesday. The moment I pulled it from the oven—all golden, bubbling, with pepperoni edges getting crispy—I knew I'd accidentally created something my entire friend group would fight over. It's comfort food with muscle-building protein baked right in, no compromise required.

I made this for my sister's book club gathering, expecting polite compliments, and instead watched four people silently devour second helpings while barely pausing their conversation—that's when I realized this dish had crossed from weeknight dinner into something people genuinely crave.

Ingredients

  • Lean ground beef (300g): The 93% lean cuts work beautifully here and brown faster without leaving pools of grease pooling in your pan.
  • Turkey or regular pepperoni (60g), sliced: Pepperoni gets slightly crispy at the edges when baked, releasing these little bursts of salty, savory flavor that honestly make the whole dish.
  • High-protein pasta (350g, penne or fusilli): Don't skip the high-protein versions—they have better structure and won't turn mushy when baked, keeping everything texturally interesting.
  • Plain Greek yogurt (250g, 0–2% fat): This is your secret weapon for a protein-packed, creamy sauce that tastes nothing like diet food and everything like indulgence.
  • Part-skim mozzarella cheese, shredded (150g): Part-skim melts beautifully and gives you that stringy, gooey texture without overwhelming the other flavors.
  • Grated Parmesan cheese (40g): A smaller amount goes a long way here, adding sharp umami depth that balances the yogurt's tanginess.
  • Large egg (1): This binds everything together and helps the sauce set properly during baking without needing cream or butter.
  • Small onion, finely chopped (1): Sweats down into the tomato base and becomes this subtle, mellow background note that grounds the whole dish.
  • Garlic, minced (2 cloves): Never skip the garlic here—those two minutes of cooking after adding it fills your kitchen with a smell that makes you actually excited to eat.
  • Canned crushed tomatoes (400g): Canned is honestly better than fresh here because it's already broken down and concentrates all the tomato flavor into one bright, cohesive base.
  • Red bell pepper, diced (1, optional but worth it): Adds sweetness and slight texture, and if you roast it a minute longer during sautéing, it caramelizes just enough to deepen everything.
  • Baby spinach, roughly chopped (100g, optional): Wilts right into the sauce and adds iron plus that slight earthiness that makes the whole thing feel more sophisticated.
  • Dried oregano and basil (1 tsp each): Dried herbs work best here because they intensify during baking and won't get lost like fresh herbs would.
  • Chili flakes (½ tsp, optional): Just enough heat to remind you this started as pizza, not to overwhelm anything.
  • Olive oil for sautéing: A light drizzle is all you need—this dish doesn't demand much fat since the yogurt and cheese sauce provide richness.

Instructions

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Heat your oven and prep:
Set the oven to 200°C (400°F) and grease your baking dish while it preheats—this takes pressure off you later when you're juggling hot pans.
Get the pasta cooking:
Dump your pasta into a large pot of salted boiling water and cook it to just al dente, maybe even a minute under what the box says, because it'll finish cooking in the oven and you want it tender, not mushy.
Build your sauce base:
While the pasta boils, heat a drizzle of olive oil in a large skillet over medium heat and sauté your chopped onion and bell pepper for about 3–4 minutes until the onion starts turning translucent and smells sweet. Add your minced garlic and let it bloom for exactly one minute—any longer and it gets bitter, any shorter and you miss that fragrant moment.
Brown the beef:
Crumble your lean ground beef into the pan and cook, breaking it up constantly with a spoon, until it's completely browned with no pink remaining. If you see excess fat pooling (unlikely with 93% lean, but possible), drain it off quickly.
Finish the tomato mixture:
Stir in your crushed tomatoes, dried oregano, basil, chili flakes if you're using them, and any spinach you've chosen to include. Let this simmer gently for about 5 minutes so the flavors actually meld together instead of staying separate.
Make your yogurt cheese sauce:
In a separate bowl, mix your Greek yogurt, half of the shredded mozzarella, Parmesan, and that one egg until the mixture is completely smooth with no streaks of yogurt visible. Season very lightly with salt and pepper—remember the cheese is already salty.
Combine everything:
In a large bowl, fold together your cooked al dente pasta, the entire beef-tomato mixture, and the yogurt-cheese sauce until every piece of pasta is coated and the sauce feels evenly distributed. This is oddly satisfying to do and takes maybe two minutes of gentle folding.
Transfer to the baking dish:
Pour everything into your prepared baking dish and smooth the top gently. Scatter the remaining mozzarella evenly across the top, then lay your pepperoni slices on top in whatever pattern feels right to you—they'll curl slightly and get crispy edges.
Bake until golden:
Bake for 20–25 minutes until the whole thing is bubbling around the edges and the top is golden brown, which usually means the inside is completely set and hot all the way through. Let it rest for exactly 5 minutes before serving so it sets just enough to scoop cleanly without being cold.
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Cheesy High-Protein Pizza Pasta Bake served in a white dish, ready for a hearty family dinner. Save
Cheesy High-Protein Pizza Pasta Bake served in a white dish, ready for a hearty family dinner. | frizplo.com

My neighbor stopped by while this was baking and the smell alone made her ask for the recipe before she'd even tasted it. That's the moment I realized this dish had this genuine, uncomplicated appeal that transcends fitness trends or dietary restrictions—it's just really good, satisfying food.

The Yogurt Swap That Changed Everything

Using Greek yogurt instead of heavy cream or ricotta felt like cheating at first, like I was cutting corners on comfort food, but then I realized the tanginess actually brightens all the tomato and meat flavors instead of muting them. The protein boost is real—you're not sacrificing taste for nutrition, you're genuinely getting both.

Why High-Protein Pasta Matters Here

Regular pasta would probably work, but high-protein versions have a sturdier structure that stands up to baking without turning into a sad, limp situation. The texture difference is subtle but noticeable, and if you're already making this dish once a week like I do, that texture quality becomes something you actually appreciate.

Making It Your Own

The beauty of this dish is how it welcomes your experiments without falling apart. I've thrown in mushrooms, olives, roasted red peppers, extra garlic—almost everything works because the yogurt-tomato base is forgiving and the cheese ties everything together. The only rule is don't overcomplicate it, because that's when you lose the simplicity that makes it so reliable to cook on a random Tuesday night.

  • Substitute ground turkey or chicken for the beef if you want to dial down the richness without sacrificing protein.
  • Add mushrooms or olives for deeper pizza-like complexity, but don't exceed 150g total or the moisture content gets weird.
  • Use whole wheat or gluten-free high-protein pasta depending on what your body needs, and you won't notice the difference at all.
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Close-up of creamy High-Protein Pizza Pasta Bake showing penne pasta, lean beef, and melted mozzarella. Save
Close-up of creamy High-Protein Pizza Pasta Bake showing penne pasta, lean beef, and melted mozzarella. | frizplo.com

This became my answer to the impossible question of how to eat something that tastes like pure comfort while actually fueling your body the way you want it to. Make it once, and it'll probably become as regular in your rotation as it has in mine.

Recipe FAQ

Can I make this ahead of time?

Yes, assemble the entire dish up to 24 hours in advance, cover tightly, and refrigerate. Bake when ready, adding 5-10 extra minutes if baking cold from the refrigerator.

What pasta shapes work best?

Penne and fusilli are ideal because their ridges and curves hold the sauce well. Rotini or macaroni also work. Avoid smooth shapes like spaghetti as they won't capture the thick sauce properly.

Can I freeze leftovers?

Absolutely. Portion cooled leftovers into airtight containers and freeze for up to 3 months. Thaw overnight in the refrigerator and reheat in the microwave or oven at 180°C until hot throughout.

Is Greek yogurt necessary?

The Greek yogurt creates a creamy sauce while adding protein. You can substitute with sour cream or ricotta cheese, though the protein content will be slightly lower and the texture may differ.

How do I know when it's done baking?

The dish is ready when the cheese is fully melted and golden brown on top, and you see bubbles around the edges. The center should feel hot when you insert a knife.

High-Protein Pizza Pasta Bake

Hearty casserole combining pizza flavors with creamy yogurt-cheese sauce, lean beef, and pepperoni baked with pasta until golden.

Prep duration
20 min
Time to cook
30 min
Complete duration
50 min
Created by Madison Young

Classification Cozy Dinner Plates

Complexity Level Easy

Cultural Origin American-Italian

Output 6 Portion Count

Dietary requirements None specified

Components

Proteins

01 10.5 oz lean ground beef
02 2 oz turkey or regular pepperoni, sliced

Pasta

01 12 oz high-protein pasta such as penne or fusilli

Cheese and Yogurt Sauce

01 1 cup plain Greek yogurt, 0 to 2 percent fat
02 1.5 cups part-skim mozzarella cheese, shredded
03 0.25 cup grated Parmesan cheese
04 1 large egg

Vegetables

01 1 small onion, finely chopped
02 2 cloves garlic, minced
03 14 oz canned crushed tomatoes
04 1 red bell pepper, diced (optional)
05 3.5 oz baby spinach, roughly chopped (optional)

Spices and Seasonings

01 1 teaspoon dried oregano
02 1 teaspoon dried basil
03 0.5 teaspoon chili flakes (optional)
04 Salt and black pepper to taste
05 Olive oil for sautéing

Directions

Step 01

Preheat oven and prepare baking dish: Preheat oven to 400°F. Grease a large 9x13-inch baking dish with oil or cooking spray.

Step 02

Cook pasta to al dente: Cook pasta in a large pot of salted boiling water until just al dente. Drain and set aside.

Step 03

Sauté vegetables: Heat olive oil in a large skillet over medium heat. Add chopped onion and bell pepper if using; sauté for 3 to 4 minutes until softened.

Step 04

Bloom garlic: Add minced garlic to the skillet and cook for 1 minute until fragrant.

Step 05

Brown ground beef: Add lean ground beef to the skillet and cook, breaking it apart with a spoon, until browned and cooked through. Drain excess fat if needed.

Step 06

Simmer tomato sauce: Stir in crushed tomatoes, oregano, basil, chili flakes if using, and spinach if using. Simmer for 5 minutes. Season with salt and pepper to taste.

Step 07

Prepare yogurt-cheese sauce: In a bowl, whisk together Greek yogurt, half of the mozzarella, Parmesan, and egg until smooth. Season lightly with salt and pepper.

Step 08

Combine all components: Transfer cooked pasta to a large bowl. Add the beef-tomato mixture and yogurt-cheese sauce. Mix thoroughly until well combined.

Step 09

Assemble casserole: Transfer the combined mixture to the prepared baking dish. Top with remaining mozzarella and arrange pepperoni slices evenly over the surface.

Step 10

Bake until golden: Bake for 20 to 25 minutes, or until the casserole is bubbly and golden brown. Let rest for 5 minutes before serving.

Necessary tools

  • Large pot for pasta cooking
  • Large skillet for browning beef and sautéing vegetables
  • Mixing bowls for sauce preparation and component combining
  • 9x13-inch baking dish for casserole assembly
  • Knife and cutting board for ingredient preparation
  • Spoon or spatula for stirring and combining ingredients

Allergy details

Review each component for potential allergens and seek professional healthcare advice if you're uncertain.
  • Contains milk from cheese and yogurt
  • Contains egg
  • Contains wheat from pasta unless gluten-free variety is used
  • Pre-sliced pepperoni may contain soy or gluten as thickening agents

Nutritional breakdown (per portion)

These values are provided as estimates only and shouldn't replace professional medical guidance.
  • Energy Content: 420
  • Fats: 13 g
  • Carbohydrates: 39 g
  • Proteins: 37 g