Cajun Chicken Alfredo

Featured in: Cozy Dinner Plates

This vibrant dish combines spicy Cajun-seasoned chicken with silky, creamy Alfredo sauce and perfectly cooked pasta for an unforgettable fusion meal. The chicken is seasoned and pan-seared until golden, while the sauce is made from scratch with butter, garlic, heavy cream, and freshly grated Parmesan cheese.

Ready in just 40 minutes with minimal prep work, this medium-difficulty dish serves 4 and brings Southern flair to Italian comfort food. Customize with extra vegetables like bell peppers or spinach, or substitute shrimp for chicken. Pairs beautifully with crisp white wine.

Updated on Sun, 18 Jan 2026 13:23:00 GMT
Golden-brown Cajun chicken strips resting on a creamy bowl of Cajun Chicken Alfredo pasta, garnished with fresh parsley and extra Parmesan. Save
Golden-brown Cajun chicken strips resting on a creamy bowl of Cajun Chicken Alfredo pasta, garnished with fresh parsley and extra Parmesan. | frizplo.com

The smell of garlic hitting hot butter still pulls me straight back to a Tuesday night when I had nothing but fettuccine, cream, and a jar of Cajun spice I'd bought on a whim. I was craving something rich but didn't want plain Alfredo, so I dusted two chicken breasts with that brick-red seasoning and let them sizzle. The kitchen filled with smoke and spice, and when I tossed everything together, I realized I'd stumbled onto something I'd crave for years. Now it's the dish I make when I want comfort with a little attitude.

I served this to friends who claimed they didn't like spicy food, and they went back for seconds anyway. One of them scraped her plate clean with a piece of bread and asked if I'd opened a restaurant without telling anyone. It's become my go-to when I want to impress without spending all day in the kitchen, and it never fails to get that quiet moment when everyone stops talking and just eats.

Ingredients

  • Boneless, skinless chicken breasts: I slice these thin if they're thick so they cook evenly and don't dry out, and I always let them rest before cutting.
  • Cajun seasoning: This is where the magic lives, look for blends with paprika, garlic, and cayenne, and don't be shy with it.
  • Olive oil: Just enough to get a good sear on the chicken without making the pan smoke too much.
  • Fettuccine or linguine: I prefer fettuccine because it holds the sauce better, but any long pasta works if that's what you have.
  • Unsalted butter: Lets you control the salt level, especially since Parmesan and Cajun seasoning both bring plenty.
  • Garlic: Fresh minced garlic is non-negotiable here, it blooms in the butter and makes the whole dish smell like heaven.
  • Heavy cream: This is what makes the sauce luscious and cling to every strand of pasta.
  • Freshly grated Parmesan cheese: The pre-grated stuff doesn't melt the same way, invest two minutes in grating your own.
  • Black pepper, salt, and red pepper flakes: These balance the richness and let you dial up the heat if you want.
  • Fresh parsley: A handful of green at the end makes it look alive and adds a little freshness to cut through the cream.

Instructions

Product image
Deep clean greasy stovetops, countertops, sinks, and tiles using powerful steam after everyday cooking.
Check price on Amazon
Boil the pasta:
Get your water rolling with a generous pinch of salt, then cook the fettuccine until it still has a little bite. Save half a cup of that starchy water before you drain, it's your secret weapon for loosening the sauce later.
Season and cook the chicken:
Pat the chicken dry so the seasoning sticks, then rub Cajun spice all over both sides. Heat olive oil in a large skillet until it shimmers, then lay the chicken in and let it sear without moving it for five to six minutes per side until it's golden and cooked through.
Rest and slice:
Pull the chicken off the heat and let it sit for a couple minutes so the juices settle. Slice it into strips and set aside.
Build the Alfredo base:
In the same skillet, melt butter over medium heat and toss in the garlic, stirring for about thirty seconds until it smells toasty. Pour in the cream and whisk gently, bringing it to a bare simmer without letting it boil over.
Thicken the sauce:
Stir in the Parmesan, black pepper, salt, and red pepper flakes if you like heat. Let it simmer for two to three minutes, whisking now and then, until it coats the back of a spoon.
Toss it all together:
Add the drained pasta to the skillet and toss until every strand is coated in sauce. If it looks tight, splash in some reserved pasta water a little at a time.
Finish with chicken and garnish:
Nestle the sliced Cajun chicken into the pasta, toss gently, then hit it with fresh parsley and extra Parmesan. Serve it hot, straight from the skillet if you want to be dramatic.
Product image
Deep clean greasy stovetops, countertops, sinks, and tiles using powerful steam after everyday cooking.
Check price on Amazon
Close-up of fettuccine noodles coated in silky Alfredo sauce, tossed with spiced Cajun chicken and a sprinkle of red pepper flakes. Save
Close-up of fettuccine noodles coated in silky Alfredo sauce, tossed with spiced Cajun chicken and a sprinkle of red pepper flakes. | frizplo.com

I made this for my mom once after she'd had a long week, and she sat at the table twirling her fork in silence for a solid minute before saying it tasted like a hug. That's when I knew this wasn't just dinner, it was the kind of meal that could turn a bad day around. Now whenever someone I care about needs comfort, this is what I cook.

Making It Your Own

If you want more color and crunch, toss in sliced bell peppers or a handful of baby spinach right before you add the pasta. I've also swapped the chicken for shrimp when I'm feeling fancy, and it cooks even faster. For a lighter version, you can cut the cream with half-and-half, though the sauce won't be quite as thick. Sometimes I throw in sun-dried tomatoes for a tangy bite that plays nicely with the spice.

What to Serve Alongside

This dish is rich enough to stand on its own, but a simple green salad with lemon vinaigrette helps balance the cream. Garlic bread is always a crowd-pleaser, even if it's overkill on the garlic. I like to pour a crisp white wine like Sauvignon Blanc, the acidity cuts through the richness and cools down the Cajun heat just enough.

Storing and Reheating

Leftovers keep in an airtight container in the fridge for up to three days, and honestly, they taste even better the next day once the flavors have mingled. When reheating, add a splash of cream or milk to bring the sauce back to life, and warm it gently on the stove over low heat. The microwave works in a pinch, just stir halfway through and don't blast it on high or the sauce will separate.

  • Store chicken and pasta together so the flavors keep soaking in.
  • Reheat in a skillet with a little butter for the best texture.
  • Don't freeze this, cream-based sauces get grainy when thawed.
Product image
Easily open jars, bottles, and cans while cooking, making meal prep smoother and less frustrating.
Check price on Amazon
A comforting plate of Cajun Chicken Alfredo with steam rising, paired with a glass of white wine on a rustic kitchen table. Save
A comforting plate of Cajun Chicken Alfredo with steam rising, paired with a glass of white wine on a rustic kitchen table. | frizplo.com

This is the kind of recipe that makes you look like you know what you're doing, even if you're winging it. Make it once and it'll earn a permanent spot in your rotation.

Recipe FAQ

Can I make this dish ahead of time?

While best served fresh, you can prepare individual components in advance. Cook the pasta and chicken separately, then refrigerate. The Alfredo sauce is best made fresh, but can be reheated gently over low heat with a splash of reserved pasta water to restore creaminess.

How can I adjust the heat level?

Control the spice by adjusting the amount of Cajun seasoning on the chicken or adding red pepper flakes to the sauce. Start with less seasoning and increase gradually to your preference. You can also reduce heat by using a mild Cajun blend instead of a traditional spicy version.

What pasta shape works best?

Fettuccine and linguine are ideal choices as their wide, flat surfaces hold the creamy sauce beautifully. Pappardelle is another excellent option. Avoid thin pasta like angel hair, which can become overcoated and heavy with this rich sauce.

How do I prevent the sauce from breaking or separating?

Maintain medium heat throughout and never bring the cream to a rapid boil. Whisk constantly when adding the cream and stir frequently while it simmers. Add Parmesan gradually and off heat if possible. If separation occurs, whisk in a tablespoon of cold pasta water to emulsify.

What are good substitutes for heavy cream?

Half-and-half can replace heavy cream but will yield a lighter sauce. Greek yogurt or mascarpone creates a tangier version. For dairy-free options, try cashew cream or oat-based alternatives, though the texture and richness will differ slightly from traditional Alfredo.

Can I add vegetables to this dish?

Absolutely. Sauté bell peppers, mushrooms, spinach, or broccoli in the skillet before making the sauce, or add them directly to the sauce for the final 2-3 minutes. Roasted sun-dried tomatoes also complement the Cajun-Alfredo combination beautifully.

Cajun Chicken Alfredo

Spicy Cajun-seasoned chicken combined with creamy Alfredo sauce and fettuccine. A delicious Southern-Italian fusion ready in 40 minutes.

Prep duration
15 min
Time to cook
25 min
Complete duration
40 min
Created by Madison Young

Classification Cozy Dinner Plates

Complexity Level Medium

Cultural Origin American Cajun-Italian Fusion

Output 4 Portion Count

Dietary requirements None specified

Components

Chicken

01 2 large boneless, skinless chicken breasts
02 1 tablespoon Cajun seasoning
03 1 tablespoon olive oil

Pasta

01 12 ounces fettuccine or linguine pasta

Alfredo Sauce

01 2 tablespoons unsalted butter
02 3 cloves garlic, minced
03 1 1/2 cups heavy cream
04 1 cup freshly grated Parmesan cheese
05 1/4 teaspoon ground black pepper
06 1/4 teaspoon salt
07 1/4 teaspoon red pepper flakes, optional

Garnish

01 2 tablespoons chopped fresh parsley
02 Extra grated Parmesan for serving

Directions

Step 01

Cook the pasta: Bring a large pot of salted water to a boil. Add fettuccine and cook according to package instructions until al dente. Reserve 1/2 cup pasta water and drain remainder. Set aside.

Step 02

Prepare the chicken: Pat chicken breasts dry and rub evenly with Cajun seasoning.

Step 03

Sear the chicken: Heat olive oil in a large skillet over medium-high heat. Add chicken breasts and cook for 5 to 6 minutes per side until golden and cooked through, reaching an internal temperature of 165°F. Remove from skillet, let rest for 2 to 3 minutes, then slice into strips.

Step 04

Create the Alfredo sauce: In the same skillet over medium heat, melt butter. Add minced garlic and sauté for 30 seconds until fragrant. Pour in heavy cream, whisking constantly, and bring to a gentle simmer without boiling.

Step 05

Season and thicken the sauce: Stir in Parmesan cheese, black pepper, salt, and red pepper flakes if using. Simmer for 2 to 3 minutes until sauce thickens. Add reserved pasta water one tablespoon at a time if sauce becomes too thick.

Step 06

Combine components: Add cooked pasta to the skillet and toss thoroughly to coat with Alfredo sauce. Add sliced Cajun chicken and toss again until fully incorporated.

Step 07

Plate and serve: Transfer to serving plates immediately, garnishing with chopped parsley and additional grated Parmesan cheese.

Necessary tools

  • Large pot
  • Large skillet
  • Tongs
  • Chef's knife
  • Cutting board
  • Measuring cups and spoons
  • Whisk

Allergy details

Review each component for potential allergens and seek professional healthcare advice if you're uncertain.
  • Contains milk from cream, butter, and Parmesan cheese
  • Contains wheat from pasta
  • May contain eggs if using fresh pasta
  • Verify Cajun seasoning for gluten or additional allergens if sensitive

Nutritional breakdown (per portion)

These values are provided as estimates only and shouldn't replace professional medical guidance.
  • Energy Content: 670
  • Fats: 34 g
  • Carbohydrates: 54 g
  • Proteins: 40 g